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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Systems pharmacology ： ウィキペディア英語版 Systems pharmacology Systems pharmacology is the application of systems biology principles to the field of pharmacology. It seeks to understand how medicines work on various systems of the body. Instead of considering the effect of a drug to be the result of one specific drug-protein interaction, systems pharmacology considers the effect of a drug to be the outcome of the network of interactions a drug may have. In 1992, the article on systems medicine and pharmacology by B.J. Zeng was published in China, at the National Conference on Chinese and Western Medicine. Networks of interaction may include chemical-protein, protein-protein, genetic, signalling and physiological (at cellular, tissue, organ and whole body levels). Systems pharmacology uses bioinformatics and statistics techniques to integrate and interpret these networks. Systems pharmacology can be applied to drug safety studies as a complement to pharmacoepidemiology.〔"Role of systems pharmacology in understanding drug adverse events" Seth I. Berger and Ravi Iyengar Systems Biology and Medicine 2011〕 The EU-ADR has successfully incorporated systems pharmacology into their signal substantiation pipeline.〔"Automatic Filtering and substantiation of drug safety signals" Bauer-Mehren Ann et al PLOS computational Biology 2012〕 == References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Systems pharmacology」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.